[The patterns of focal reorganization of the synaptic pool at the molecular level of the cerebellar cortex in the ischemic period]

Abstract

A comparative analysis of intraneuronal relationship between Purkinje cells and granule cells zones of the cerebellar cortex molecular layer with different extent of expression of destructive and compensatory-adaptive processes was performed in rats in the dynamics of postischemic period. The ischemia was modelled by the 10 minutes long compression of the heart vascular bundle under the ethereal narcosis, Dependence between type and extent of the synaptic profile and functional state of the synapse was shown. Dynamics of changes of the synapse numerical density was demonstrated so as the regularities of the axo-spinous synapses structural organization changes during their dysfunction, destruction and interneuronal contact repair within and outside the nidi of interneuronal interrelations during 30 days of postischemic period.