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Review
. 1996 Aug;7(4):397-402.
doi: 10.1016/s0958-1669(96)80114-5.

Protein serine/threonine phosphatases

J E Villafranca  1 , C R Kissinger, H E Parge
Affiliations
Review

Protein serine/threonine phosphatases

J E Villafranca et al. Curr Opin Biotechnol. 1996 Aug.

Abstract

In the past year, the three-dimensional structures of two serine/threonine phosphatases, protein phosphatase-1 and protein phosphatase-2b (calcineurin), have been determined. The new information puts previous sequence comparisons and mutagenesis studies into a detailed structural perspective. The active-site structure and catalytic mechanism appear to be common to a variety of phosphoesterase enzymes.

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