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. 1996 Jan;70(1):556-67.
doi: 10.1016/S0006-3495(96)79602-9.

Measuring the viscoelastic properties of human platelets with the atomic force microscope

M Radmacher  1 , M Fritz, C M Kacher, J P Cleveland, P K Hansma
Affiliations

Measuring the viscoelastic properties of human platelets with the atomic force microscope

M Radmacher et al. Biophys J. 1996 Jan.

Abstract

We have measured force curves as a function of the lateral position on top of human platelets with the atomic force microscope. These force curves show the indentation of the cell as the tip loads the sample. By analyzing these force curves we were able to determine the elastic modulus of the platelet with a lateral resolution of approximately 100 nm. The elastic moduli were in a range of 1-50 kPa measured in the frequency range of 1-50 Hz. Loading forces could be controlled with a resolution of 80 pN and indentations of the platelet could be determined with a resolution of 20 nm.

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References

    1. Science. 1992 Sep 25;257(5078):1900-5 - PubMed
    1. J Biol Chem. 1994 Dec 23;269(51):32503-13 - PubMed
    1. Phys Rev Lett. 1986 Mar 3;56(9):930-933 - PubMed
    1. Science. 1994 Sep 9;265(5178):1577-9 - PubMed
    1. J Cell Biol. 1992 Sep;118(6):1421-42 - PubMed

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