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. 1996 Jan;142(1):163-71.
doi: 10.1093/genetics/142.1.163.

Mutations Modulating Raf signaling in Drosophila eye development

B J Dickson  1 , A van der Straten, M Dominguez, E Hafen
Affiliations

Mutations Modulating Raf signaling in Drosophila eye development

B J Dickson et al. Genetics. 1996 Jan.

Abstract

The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue: another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.

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References

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