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. 1996 Jan;11(1):24-6.
doi: 10.1002/mds.870110106.

Levodopa stability in solution: time course, environmental effects, and practical recommendations for clinical use

E J Pappert  1 , C Buhrfiend, J W Lipton, P M Carvey, G T Stebbins, C G Goetz
Affiliations

Levodopa stability in solution: time course, environmental effects, and practical recommendations for clinical use

E J Pappert et al. Mov Disord. 1996 Jan.

Abstract

We defined the temporal stability characteristics of levodopa/carbidopa (LD/CD) solution, and determined the effects of temperature, ascorbate, and light on LD stability over 7 days. At room temperature and without ascorbate, LD levels significantly declined by 48 h. Ascorbate prolonged stability to 72 h. Refrigeration and freezing prevented a significant decline in LD levels for the full 7 days. Light or darkness had no effect on stability. LD/CD solution, if made daily, requires no special handling and longer stability is maintained with ascorbate, refrigeration, or freezing.

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