Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 May;52(2):181-92.
doi: 10.1007/BF02789460.

Distribution of aluminum in different brain regions and body organs of rat

D Julka  1 , R K Vasishta, K D Gill
Affiliations

Distribution of aluminum in different brain regions and body organs of rat

D Julka et al. Biol Trace Elem Res. 1996 May.

Abstract

In the present study, an attempt has been made to investigate the distribution of aluminum in different regions of brain and body organs of male albino rats, following subacute and acute aluminum exposure. Aluminum was observed to accumulate in all regions of the brain with maximum accumulation in the hippocampus. Subcellular distribution of aluminum indicated that there was maximum localization in the nucleus followed by cytosolic, microsomal, and mitochondrial deposition. Elution profile of cytosolic proteins on G-75 Sephadex column revealed a substantial amount of aluminum bound to high-mol-wt protein fraction. Aluminum was also seen to compartmentalize in almost all the tissues of the body to varying extents, and the highest accumulation was in the spleen.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 1983 Apr 14;744(1):36-45 - PubMed
    1. Trends Biochem Sci. 1991 Apr;16(4):140-4 - PubMed
    1. Toxicology. 1992 Nov 30;76(2):119-32 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Nov;87(22):9024-7 - PubMed
    1. Clin Chim Acta. 1990 Dec 24;194(2-3):167-72 - PubMed

Publication types

LinkOut - more resources