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. 1996 Jul;55(7):486-8.
doi: 10.1136/ard.55.7.486.

Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases

N M Buchanan  1 , E Toubi, M A Khamashta, F Lima, S Kerslake, G R Hughes
Affiliations

Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases

N M Buchanan et al. Ann Rheum Dis. 1996 Jul.

Abstract

Objective: To study maternal and fetal outcome of pregnancy in patients with lupus who were exposed to hydroxychloroquine (HCQ).

Methods: The case records of women (n = 33) exposed to HCQ during their pregnancies (n = 36) and of 53 control patients from a single lupus pregnancy centre were reviewed to determine lupus activity, obstetric experience, and infant outcome.

Results: HCQ was not apparently teratogenic. Lupus activity and obstetric outcome in the two groups were similar.

Conclusion: HCQ continuation is probably safe during pregnancy in patients with lupus, but there is no obvious advantage in commencing treatment.

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