Successful twin pregnancy in homozygous beta-thalassemia after ovulation induction with growth hormone and gonadotropins

Abstract

Objective: To describe infertility treatment and pregnancy outcome in a patient with transfusion-dependent beta-thalassemia major and hypopituitarism.

Design: Case report.

Setting: University-affiliated infertility clinic.

Patient: Twenty-four-year-old infertile patient with homozygous beta-thalassemia.

Intervention: Co-treatment with GH and gonadotropins.

Results: Ovulation induction with clomiphene citrate or gonadotropins alone was unsuccessful. Combined treatment with hMG, hCG, and recombinant human GH followed by intrauterine insemination resulted in a viable twin pregnancy.

Conclusion: Human GH as an adjunct to hMG and hCG seems to be a sensible approach in the treatment of infertile homozygous beta-thalassemic patients among which very few pregnancies are reported.