Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1996 Jul;89(7):396-400.
doi: 10.1177/014107689608900711.

The D2 dopamine receptor gene as a determinant of reward deficiency syndrome

K Blum  1 , P J Sheridan, R C Wood, E R Braverman, T J Chen, J G Cull, D E Comings
Affiliations
Review

The D2 dopamine receptor gene as a determinant of reward deficiency syndrome

K Blum et al. J R Soc Med. 1996 Jul.

Abstract

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.

PubMed Disclaimer

References

    1. JAMA. 1990 Dec 26;264(24):3156-60 - PubMed
    1. Pharmacogenetics. 1996 Feb;6(1):73-9 - PubMed
    1. Arch Gen Psychiatry. 1991 Jul;48(7):648-54 - PubMed
    1. Arch Gen Psychiatry. 1991 Jul;48(7):655-63 - PubMed
    1. Biotechniques. 1991 Apr;10(4):436, 438, 440 - PubMed

Publication types

Substances