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. 1996 Aug 15;52(8):807-11.
doi: 10.1007/BF01923994.

Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat

S Savković  1 , S Pavlović, T Mitrović, M Joksimović, J Marjanović, V Glisin, Z Popović
Affiliations

Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat

S Savković et al. Experientia. .

Abstract

The splenomegaly and the appearance of a significant number of CFU-E (erythroid colony-forming units) and BFU-E1 (erythroid burst-forming units) in the Belgrade laboratory rat (b/b) spleen prompted us to analyse further the molecular evidence for increased hematopoietic proliferation in the b/b spleen. Messenger RNAs (mRNAs) specific for globins, proteins for iron transport and deposition and the band 3 protein were used in rat erythropoietic tissues as markers for proliferation and erythroid differentiation. In the b/b spleen, all mRNAs analysed display an erythroid-specific pattern of expression. This analysis also revealed an enhanced level of mRNA for ferritin in the +/b spleen, whereas erythrocyte-specific mRNA production was normal.

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