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. 1977 Jul 22;197(4301):393-6.
doi: 10.1126/science.877564.

Surgical removal of adipose tissue alters feeding behavior and the development of obesity in rats

I M Faust, P R Johnson, J Hirsch

Surgical removal of adipose tissue alters feeding behavior and the development of obesity in rats

I M Faust et al. Science. .

Abstract

Lipectomized and sham-operated rats were fed a high-fat diet to induce hyperphagia and rapid fat accumulation. Lipectomized rats with 25% fewer adipocytes were less hyperphagic and accumulated less fat, but their adipocytes remained equal in size to adipocytes of controls. A role for adipocyte size in fat storage regulation and food intake control is postulated.

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