doi: 10.1126/science.877571.
Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro
- PMID: 877571
- DOI: 10.1126/science.877571
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Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro
Science.
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Abstract
Delta-9-tetrahydrocannabinol (delta9-THC) inhibited the activity of lysolecithin acyl transferase, a membrane-bound lymphocyte enzyme, at concentrations above 1.3 muM. Stimulation of acyl transferase activity by concanavalin A, an early response in lymphocyte activation, was entirely abolished in the presence of delta9-THC.
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