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. 1977 Jul 29;197(4302):475-7.
doi: 10.1126/science.877571.

Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro

J H Greenberg, M E Saunders, A Mellors

Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro

J H Greenberg et al. Science. .

Abstract

Delta-9-tetrahydrocannabinol (delta9-THC) inhibited the activity of lysolecithin acyl transferase, a membrane-bound lymphocyte enzyme, at concentrations above 1.3 muM. Stimulation of acyl transferase activity by concanavalin A, an early response in lymphocyte activation, was entirely abolished in the presence of delta9-THC.

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