doi: 10.1126/science.877576.
Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity
- PMID: 877576
- DOI: 10.1126/science.877576
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Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity
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Abstract
The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.
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