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Case Reports
. 1996 Jul;135(1):106-9.
doi: 10.1046/j.1365-2133.1996.d01-943.x.

Orificial tuberculosis: detection by polymerase chain reaction

F Nachbar  1 , V Classen, T Nachbar, M Meurer, C G Schirren, K Degitz
Affiliations
Case Reports

Orificial tuberculosis: detection by polymerase chain reaction

F Nachbar et al. Br J Dermatol. 1996 Jul.

Abstract

Orificial tuberculosis (OT) is a rare manifestation of cutaneous tuberculosis in immunocompromised individuals. Due to its variable clinical features, the diagnosis may be missed at the onset of the disease. We report a 53-year-old patient who had OT and miliary spread of Mycobacterium tuberculosis to the lungs, liver, bones and skin. The diagnosis was established by polymerase chain reaction (PCR) amplification of a Mycobacterium-specific gene segment, and confirmed by culture. PCR allows the detection of mycobacterial DNA within a few days, whereas culture takes many weeks. PCR may improve the accurate diagnosis of skin tuberculosis and allow early treatment.

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