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Clinical Trial
. 1996 Mar;74(2):F129-31.
doi: 10.1136/fn.74.2.f129.

Effect of non-sucrose sweet tasting solution on neonatal heel prick responses

L A Ramenghi  1 , G C Griffith, C M Wood, M I Levene
Affiliations
Clinical Trial

Effect of non-sucrose sweet tasting solution on neonatal heel prick responses

L A Ramenghi et al. Arch Dis Child Fetal Neonatal Ed. 1996 Mar.

Abstract

A substance commercially described as 'sugar free,' used as a sweetener for paracetamol suspension, was evaluated on measures of neonatal pain. Sixty infants were randomly allocated to receive one of four solutions before heel stab blood sampling: sterile water (placebo); 25 or 50% sucrose (weight/volume); and the commercial sweet-tasting solution. There was a significant reduction in crying time and pain score 3 minutes after the painful stimulus in all groups compared with the controls. It is concluded that this sweet-tasting solution has analgesic effects as potent as those of concentrated sucrose solutions.

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Comment in

  • Pain response in neonates.
    Puntis J. Puntis J. Arch Dis Child Fetal Neonatal Ed. 1996 Sep;75(2):F144. doi: 10.1136/fn.75.2.f144-a. Arch Dis Child Fetal Neonatal Ed. 1996. PMID: 8949706 Free PMC article. No abstract available.

References

    1. Pain. 1987 Mar;28(3):395-410 - PubMed
    1. Pharmacol Biochem Behav. 1987 Mar;26(3):483-9 - PubMed
    1. N Engl J Med. 1987 Nov 19;317(21):1321-9 - PubMed
    1. Pain. 1990 Sep;42(3):295-305 - PubMed
    1. Pediatrics. 1991 Feb;87(2):215-8 - PubMed

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