In quest for a possible association between heightened social aggression and excessive alcohol drinking in the rat

Abstract

Many clinical studies show that a sizeable proportion of male alcoholics are also inclined to act violently and aggressively. Given this association in humans, we asked whether a relationship exists between ethanol intake and aggressive behaviour in laboratory rats. In a first test of the hypothesis, we measured ethanol intake in male rats made aggressive by periodic contacts with sexually active females. Although the males became significantly more aggressive, there was no concomitant enhancement of alcohol consumption. In another experiment, observations of ethanol drinking in lactating rats exhibiting maternal aggression revealed no alteration in ethanol intake relative to nonlactating control females. However, because water intake was substantially elevated in the maternal rats, there was a net decrease in ethanol preference. The final experiment examined aggressiveness in chronically food-restricted male rats. In line with previous studies, this procedure increased ethanol drinking, but it did not enhance aggressive behaviour. It is concluded that, in our rats, there is no apparent association between the level of social aggression and the voluntary intake of ethanol in a two-bottle choice paradigm. The possibility remains, though, that alcohol drinking is better related to other forms of aggression, such as defensive or predatory aggression.