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. 1976 Aug;73(8):2895-8.
doi: 10.1073/pnas.73.8.2895.

beta-endorphin is a potent analgesic agent

H H Loh, L F Tseng, E Wei, C H Li

beta-endorphin is a potent analgesic agent

H H Loh et al. Proc Natl Acad Sci U S A. 1976 Aug.

Abstract

beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of beta-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.

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References

    1. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1145-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Jun;73(6):1821-3 - PubMed
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