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. 1996 Sep;3(9):747-52.
doi: 10.1038/nsb0996-747.

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

R Hrabal, Z Chen, S James, H P Bennett, F Ni

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

R Hrabal et al. Nat Struct Biol. 1996 Sep.

Abstract

The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of beta-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.

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