Neurological and psychiatric adverse effects of anaesthetics: epidemiology and treatment

Abstract

The practice of anaesthesia has changed considerably over the past 20 to 30 years owing largely to technological advances in patient monitoring and an expanded and improved pharmacological repertoire. While patient safety in anaesthesia has greatly improved, the risk of neurological and psychiatric adverse effects of anaesthetics remains and is the focus of continued investigation. For example, a great deal of attention has recently been directed at intraoperative awareness. This adverse event can be caused by delivering an inappropriate amount or type of anaesthetic. Another risk of anaesthesia involves drug-induced unpleasant subjective states in patients. Those drugs most frequently associated with these states include ketamine, droperidol and scopolamine. This risk can often be attenuated by careful adjustment of drug dose and the use of adjunctive agents such as benzodiazepines which may produce amnesia of the unpleasant subjective state. While it is well established that modern anaesthetic drugs cause acute impairment of cognition and psychomotor functioning, there is little evidence that these drugs have long term impairing effects. Finally, a particular kind of surgery, cardiac surgery requiring cardiopulmonary bypass, can be associated with adverse neurological and psychiatric sequelae which, while not directly related to anaesthesia, are of intense interest to anaesthesiologists.