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Review
. 1996 Feb;13(1):5-17.
doi: 10.1007/BF01049674.

Glycosylation reactions--present status future directions

D M Whitfield  1 , S P Douglas
Affiliations
Review

Glycosylation reactions--present status future directions

D M Whitfield et al. Glycoconj J. 1996 Feb.

Abstract

A short review of the present status of glycosylation reactions is presented. The reactivity of both proven and newer glycosylation methods are briefly discussed. Emphasis is placed on the control of stereochemistry and regiochemistry. As well, the identification and avoidance of side reactions is covered. Polymer-supported synthesis of oligosaccharides is noted as a promising direction for eliminating some of the problems associated with purification. It is suggested that a better understanding of the mechanism of glycosylation reactions is necessary for future improvements to stereoselectivity and regioselectivity. A key advance would be methods for enhancing the reactivity of weakly nucleophilic hydroxyls.

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References

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    1. Carbohydr Res. 1993 Apr 7;242:C7-10 - PubMed
    1. Science. 1993 May 28;260(5112):1307-9 - PubMed
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