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. 1996 Jan;40(1):234-6.
doi: 10.1128/AAC.40.1.234.

Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities

S Rusconi  1 , M Moonis, D P Merrill, P V Pallai, E A Neidhardt, S K Singh, K J Willis, M S Osburne, A T Profy, J C Jenson, M S Hirsch
Affiliations

Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities

S Rusconi et al. Antimicrob Agents Chemother. 1996 Jan.

Abstract

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.

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References

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