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. 1996 Jan;40(1):260-2.
doi: 10.1128/AAC.40.1.260.

TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases

P A Bradford  1 , N V Jacobus, N Bhachech, K Bush
Affiliations

TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases

P A Bradford et al. Antimicrob Agents Chemother. 1996 Jan.

Abstract

TEM-28 (pI 6.1), expressed by an Escherichia coli clinical isolate, is a novel beta-lactamase which hydrolyzed ceftazidime, cefotaxime, and aztreonam with rates of 25, 1.1, and 5.6, respectively, relative to that for benzylpenicillin (100). The nucleotide sequence of blaTEM-28 differed from that of blaTEM-1 by two base changes, resulting in amino acid substitutions of Arg-164 to His and Glu-240 to Lys.

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References

    1. J Gen Microbiol. 1975 May;88(1):169-78 - PubMed
    1. Antimicrob Agents Chemother. 1995 May;39(5):1199-200 - PubMed
    1. Antimicrob Agents Chemother. 1982 Jan;21(1):85-92 - PubMed
    1. Infection. 1987 Jul-Aug;15(4):257-9 - PubMed
    1. J Antimicrob Chemother. 1989 Jul;24(1):82-4 - PubMed

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