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. 1996 Sep 3;93(18):9850-7.
doi: 10.1073/pnas.93.18.9850.

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development

P M Smallwood  1 , I Munoz-Sanjuan, P Tong, J P Macke, S H Hendry, D J Gilbert, N G Copeland, N A Jenkins, J Nathans
Affiliations

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development

P M Smallwood et al. Proc Natl Acad Sci U S A. .

Abstract

Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.

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References

    1. Eur J Neurosci. 1989 May;1(3):222-246 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3446-50 - PubMed
    1. EMBO J. 1986 May;5(5):919-24 - PubMed
    1. Nat Genet. 1993 Aug;4(4):373-80 - PubMed
    1. J Biol Chem. 1995 Jan 6;270(1):33-6 - PubMed

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