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. 1994 Winter;1(4):337-48.
doi: 10.1089/cmb.1994.1.337.

On the complexity of multiple sequence alignment

L Wang  1 , T Jiang
Affiliations

On the complexity of multiple sequence alignment

L Wang et al. J Comput Biol. 1994 Winter.

Abstract

We study the computational complexity of two popular problems in multiple sequence alignment: multiple alignment with SP-score and multiple tree alignment. It is shown that the first problem is NP-complete and the second is MAX SNP-hard. The complexity of tree alignment with a given phylogeny is also considered.

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