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. 1996 Feb 1;7(1):72-7.
doi: 10.1016/s0958-1669(96)80098-x.

Protein adsorption on solid surfaces

Affiliations

Protein adsorption on solid surfaces

V Hlady V et al. Curr Opin Biotechnol. .

Abstract

The research field of protein adsorption on surfaces appears to be as popular as ever. In the past year, several hundred published papers tackled problems ranging from fundamental aspects of protein surface interactions to applied problems of surface blood compatibility and protein surface immobilization. Although some parts of the protein adsorption process, such as kinetics and equilibrium interactions, can be accurately predicted, other aspects, such as the extent and the rate of protein conformational change, are still somewhat uncertain. The whole field is ripe for a comprehensive theory on protein adsorption.

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References

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    1. Haynes CA, Norde W. Globular proteins at solid/liquid interfaces. Colloids Surfaces [B] 1994;2:517–566. A comprehensive overview on the driving forces involved in protein adsorption. The basic physical processes determining the conformation of a protein and its interaction with interfaces are evaluated using a thermodynamic approach.
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