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Review
. 1996 Feb;6(1):82-6.
doi: 10.1016/s0959-437x(96)90015-5.

RET oncogene

Y F Mak  1 , B A Ponder
Affiliations
Review

RET oncogene

Y F Mak et al. Curr Opin Genet Dev. 1996 Feb.

Abstract

RET mutations have been identified as the underlying cause of two congenital diseases that predominately affect tissues of neural crest origin: the MEN 2 cancer syndromes and a proportion of cases of dominantly inherited Hirschsprung disease, a disorder of gut development. This review summarizes the disease-causing mutations and our present understanding of their possible effects on RET protein function.

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