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Clinical Trial
. 1996 Sep;91(9):1814-6.

Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis

R al-Sabbagh  1 , F A Sinicrope, J H Sellin, Y Shen, L Roubein
Affiliations
  • PMID: 8792704
Clinical Trial

Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis

R al-Sabbagh et al. Am J Gastroenterol. 1996 Sep.

Abstract

Background: Radiation proctitis is a common complication of abdominal and pelvic radiotherapy; unfortunately, there is no established effective therapy for radiation proctitis. Short-chain fatty acids (SCFA) have been effectively used to treat a variety of colitides. We sought to determine whether SCFA enemas have a role in the treatment of radiation proctitis.

Methods: Seven patients completed an open-labeled, pilot study to evaluate the effect of SCFA on clinical, endoscopic, and pathological parameters of radiation proctitis.

Results: Four weeks of treatment with SCFA enemas resulted in clinical improvement in all patients. There were modest, but not significant, changes in endoscopic and pathological parameters.

Conclusion: SCFA are a promising therapeutic option in radiation proctitis.

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