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Review
. 1996 Jun 1;6(6):676-8.
doi: 10.1016/s0960-9822(09)00447-3.

Disease mechanism: unravelling Wiskott-Aldrich syndrome

T Kirchhausen  1 , F S Rosen
Affiliations
Free article
Review

Disease mechanism: unravelling Wiskott-Aldrich syndrome

T Kirchhausen et al. Curr Biol. .
Free article

Abstract

The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.

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