Processing of modulation frequency in the dorsal cochlear nucleus of the guinea pig: sinusoidal frequency-modulated tones

Abstract

Frequency- and amplitude-modulated (FM and AM, respectively) tones are important information-bearing elements in voice sounds and can also be produced by the spatial movement of sound sources. Zhao and Liang (1995) recently reported the response features of dorsal cochlear nucleus (DCN) neurons to AM tones. In the present study, the responses of the guinea pig DCN neurons to sinusoidal FM (SFM) tones were examined. Discharges of the DCN units to the SFM tones phase-locked to the stimulus modulation frequencies (fm). The phase-locked discharge patterns existed over broad ranges of modulation parameters and at stimulus levels as high as 95 dB SPL or modulation depths (dm) as low as 2%. Robust phase-locking to the fm was observed in samples of all DCN unit types studied. The means of best fm (Bfm) and upper limit fm (ULfm) of all recorded units were 510 Hz and 940 Hz, respectively. Pauser/Buildup (P/B) units had mean maximum synchronization index (SImax) of 0.57. ON units had the highest Bfm with the mean of 646 Hz and subtype ON-S showed the highest mean of SImax at 0.63. Phase-locking to the fm was independent of discharge rates and existed even when the discharge rates were reduced to the background spontaneous rate (SR). A few units showed stronger synchronous responses to the square and triangular FM stimuli instead of the SFM tones. The relationship between the modulated responses and the unit's response area were further examined. The fm phase-locking occurred to modulation bands (or frequency ranges) within the response area, with the modulation bands as narrow as +/- 160 Hz in the central inhibitory areas of the type IV units. As the width of the modulation band changed within a unit's response area, the phases of the fm phase-locked responses of P/B units linearly changed while for Onset units, the change was lesser. The P/B and Onset units had a pi phase shift and a pi/2 phase change, respectively, as carrier frequencies (fc5) passed through characteristic frequencies (CF) and the excitatory/inhibitory response boundaries. The phase-locked responses to the fms were dependent on the SR but were independent of the CF. Low-SR (< or = 2 spikes/s) units had higher synchronization of responses to the fm than the high-SR (> 2 spikes/s) units (SImax = 0.64 and 0.42 respectively). These results suggest that the temporal characteristics of the fm is effectively represented in the responses of DCN units to the SFM tones. Such temporal encoding behavior can play an important role in the processing of the complex sounds in the auditory system. These results also have implications for a possible role for the DCN is in identifying the spatial movement of a sound source.