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Review
. 1996 Aug;8(4):526-30.
doi: 10.1016/s0952-7915(96)80041-0.

Primary and secondary immune responses to Listeria monocytogenes

J T Harty  1 , L L Lenz, M J Bevan
Affiliations
Review

Primary and secondary immune responses to Listeria monocytogenes

J T Harty et al. Curr Opin Immunol. 1996 Aug.

Abstract

Recent studies have revealed the complexity of cytokine and cellular interactions required for resistance to primary Listeria monocytogenes infection and have illustrated that resistance to secondary infection may occur through multiple pathways. Analyses of Listeria epitope generation and the specificity of protective CD8(+) T cells have suggested that future research should focus on secreted protein antigens in specific resistance to infection and have increased our understanding of Listeria antigens presented by MHC class l-b molecules.

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References

    1. Portnoy DA, Chakraborty T, Goebel W, Cossart P. Molecular determinants of Listeria monocytogenes pathogenesis. Infecf Immun. 1992;60:1263–1267. - PMC - PubMed
    1. Bancroft GJ, Schreiber RD, Unanue ER. Natural immunity: a T-cell-independent pathway of macrophage activation, defined in the scid mouse. Immunol Rev. 1991;124:5–24. - PubMed
    1. Tripp CS, Wolf SF, Unanue ER. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA. 1993;90:3725–3729. - PMC - PubMed
    1. Hsieh CS, Macatonia SE, O’Garra A, Murphy KM. Pathogen-induced Th1 phenotype development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent. Int Immunol. 1993;5:371–382. - PubMed
    1. Conlan JW, North RJ. Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J Exp Med. 1994;179:259–268. - PMC - PubMed

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