Neurotrophins and activity-dependent development of the neocortex
- PMID: 8794047
- DOI: 10.1016/s0959-4388(96)80017-1
Neurotrophins and activity-dependent development of the neocortex
Abstract
A number of recent results suggest that neurotrophins play an important role in early development as well as in the later, activity-dependent processes important for the final shaping of cortical connections. Many neurotrophins and their receptors are regulated in parallel with the 'critical period' in development, and their application to the neocortex can dramatically alter the functional organization of the cortex, as well as the morphological properties of neocortical neurons. In addition, recent data show that a different phenomenon of synaptic plasticity, hippocampal long-term potentiation, also critically depends on neurotrophins. Thus, neurotrophins may play a role in linking functional modifications of synapses to the morphological effects of synaptic stabilization and rearrangement, as observed in the neocortex.
Similar articles
-
Neurotrophins and cortical development.Results Probl Cell Differ. 2002;39:89-112. doi: 10.1007/978-3-540-46006-0_5. Results Probl Cell Differ. 2002. PMID: 12353470 Review.
-
Neurotrophins as synaptic modulators.Nat Rev Neurosci. 2001 Jan;2(1):24-32. doi: 10.1038/35049004. Nat Rev Neurosci. 2001. PMID: 11253356 Review.
-
Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS.Gen Pharmacol. 1998 Nov;31(5):667-74. doi: 10.1016/s0306-3623(98)00190-6. Gen Pharmacol. 1998. PMID: 9809461 Review.
-
Roles of neurotrophins on synaptic development and functions in the central nervous system.Hum Cell. 1998 Sep;11(3):157-65. Hum Cell. 1998. PMID: 10086277 Review.
-
Neurotrophins and synaptic plasticity.Annu Rev Neurosci. 1999;22:295-318. doi: 10.1146/annurev.neuro.22.1.295. Annu Rev Neurosci. 1999. PMID: 10202541 Review.
Cited by
-
Development and plasticity of the primary visual cortex.Neuron. 2012 Jul 26;75(2):230-49. doi: 10.1016/j.neuron.2012.06.009. Neuron. 2012. PMID: 22841309 Free PMC article. Review.
-
Long-term enhancement of central synaptic transmission by chronic brain-derived neurotrophic factor treatment.J Neurosci. 1999 Aug 15;19(16):7025-36. doi: 10.1523/JNEUROSCI.19-16-07025.1999. J Neurosci. 1999. PMID: 10436057 Free PMC article.
-
A neural model of normal and abnormal learning and memory consolidation: adaptively timed conditioning, hippocampus, amnesia, neurotrophins, and consciousness.Cogn Affect Behav Neurosci. 2017 Feb;17(1):24-76. doi: 10.3758/s13415-016-0463-y. Cogn Affect Behav Neurosci. 2017. PMID: 27905080 Free PMC article.
-
Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies.Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):755-80. doi: 10.1007/s10571-006-9048-6. Epub 2006 Sep 22. Cell Mol Neurobiol. 2006. PMID: 17029036 Free PMC article.
-
Expression of the nerve growth factor receptors TrkA and p75NTR in the visual cortex of the rat: development and regulation by the cholinergic input.J Neurosci. 2002 Feb 1;22(3):912-9. doi: 10.1523/JNEUROSCI.22-03-00912.2002. J Neurosci. 2002. PMID: 11826120 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources