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. 1996 Oct;70(10):7280-4.
doi: 10.1128/JVI.70.10.7280-7284.1996.

A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus

P Pineau  1 , A Marchio, B Terris, M G Mattei, Z X Tu, P Tiollais, A Dejean
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A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus

P Pineau et al. J Virol. 1996 Oct.

Abstract

Integrated hepatitis B virus (HBV) DNA is found in the great majority of human hepatocellular carcinomas, suggesting that these viral integrations may be implicated in liver oncogenesis. Besides the insertional mutagenesis characterized in a few selected cases and the contribution of viral transactivators to cell transformation to malignancy, HBV has been shown to generate gross chromosomal rearrangements potentially involved in carcinogenesis. Here, we report a t(3;8) chromosomal translocation present in a hepatocellular carcinoma developed in noncirrhotic liver tissue. One side of the translocation, in 8p23, is shown to be in the vicinity of the carboxypeptidase N gene, a locus that is heavily transcribed in liver tissue and frequently deleted in hepatocellular carcinomas and other epithelial tumors. The other side of the translocation, in 3q27-29, is widely implicated in several types of translocations occurring in different malignancies, such as large-cell lymphomas. The present data strongly support a model in which HBV-induced chromosomal rearrangements play a key role during multistep liver oncogenesis.

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