Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Sep;62(9):3477-9.
doi: 10.1128/aem.62.9.3477-3479.1996.

Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans

D Zhang  1 , E B Hansen Jr, J Deck, T M Heinze, J B Sutherland, C E Cerniglia
Affiliations

Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans

D Zhang et al. Appl Environ Microbiol. 1996 Sep.

Abstract

The metabolism of the antihistamine azatadine by the zygomycete fungus Cunninghamella elegans ATCC 9245 was investigated. Within 72 h from the addition of the drug to 48-h-old cultures grown in Sabouraud dextrose broth, 95% of azatadine was biotransformed. Two major metabolites, 7-hydroxyazatadine (25%) and 8-hydroxyazatadine (50%), and two minor metabolites, N-desmethylazatadine and 9-hydroxyazatadine, were isolated by high-performance liquid chromatography and characterized by mass spectrometric and proton nuclear magnetic resonance spectroscopic analyses.

PubMed Disclaimer

References

    1. Agents Actions. 1974 Oct;4(4):264-70 - PubMed
    1. Curr Med Res Opin. 1979;6(1):62-9 - PubMed
    1. Br J Clin Pract. 1980 Mar;34(3):75-9 - PubMed
    1. Australas J Dermatol. 1981 Aug;22(2):53-5 - PubMed
    1. J Int Med Res. 1983;11(2):101-7 - PubMed

Publication types

MeSH terms