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. 1996 Aug;44(8):1535-9.
doi: 10.1248/cpb.44.1535.

A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka

C F Hossain  1 , E Okuyama, M Yamazaki
Affiliations
Free article

A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka

C F Hossain et al. Chem Pharm Bull (Tokyo). 1996 Aug.
Free article

Abstract

Monankarins A-F (1-6), a new series of pigments having conjugated pyrano-coumarin skeleton have been isolated from Monascus anka. Their structures have been elucidated by spectroscopic means and chemical modification. Monankarins A-D exhibited monoamine oxidase (MAO) inhibitory activity, while the activity was not observed in monankarins E and F or some other simple coumarins. Monankarin C (3) showed stronger inhibition of MAO-B than MAO-A in mice brain. However, the specificity was not found in mice liver MAO.

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