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. 1996 May;19(5):298-303.
doi: 10.1007/BF03347866.

Histamine receptors and bioeffects on clonal parathyroid endothelial cells

U Frediani  1 , S Benvenuti, L Masi, A L Tanini, M L Brandi
Affiliations

Histamine receptors and bioeffects on clonal parathyroid endothelial cells

U Frediani et al. J Endocrinol Invest. 1996 May.

Abstract

Using a clonal line of bovine parathyroid endothelial cells (BPE-1) we defined the presence on these cells of a histamine H2 receptor and characterized its pharmacological properties. Interaction of histamine with its receptor induced an increase of cAMP accumulation in a dose- and time-dependent fashion. This effect appears unique for parathyroid endothelial cells, in fact, clonal parathyroid epithelial cells did not exhibit a similar response. No effect of histamine was observed on BPE-1 cell proliferation.

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