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Comparative Study
. 1996 Jan-Feb;3(1):20-2.

Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of beta-hCG and unconjugated estriol with controls: no need to adjust as with alpha-fetoprotein

M I Evans  1 , J E O'Brien, E Dvorin, E L Krivchenia, A Drugan, R F Hume Jr, M P Johnson
Affiliations
  • PMID: 8796802
Comparative Study

Similarity of insulin-dependent diabetics' and non-insulin-dependent diabetics' levels of beta-hCG and unconjugated estriol with controls: no need to adjust as with alpha-fetoprotein

M I Evans et al. J Soc Gynecol Investig. 1996 Jan-Feb.

Abstract

Objective: To determine if the same systematic alteration of serum values seen for alpha-fetoprotein (AFP) in diabetic patients is also seen for beta-hCG and unconjugated estriol (uE3).

Methods: Serum AFP, beta-hCG, and uE3 results were obtained in 18,639 patients for whom complete follow-up information was obtained. Patients were divided into euglycemic (n = 18,088), insulin-requiring diabetics (n = 104), and non-insulin-requiring diabetics (n = 437), as well as by race.

Results: The 20% adjustment used for AFP appropriately corrects serum values. No such systematic variation is seen for either beta-hCG or uE3 by glycemic status or race.

Conclusion: No adjustment for beta-hCG or uE3 is necessary for diabetes for biochemical screening programs.

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