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. 1977 Jun;11(6):946-51.
doi: 10.1128/AAC.11.6.946.

Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate

B Eriksson, E Helgstrand, N G Johansson, A Larsson, A Misiorny, J O Norén, L Philipson, K Stenberg, G Stening, S Stridh, B Oberg

Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate

B Eriksson et al. Antimicrob Agents Chemother. 1977 Jun.

Abstract

Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and GpC-stimulated influenza virus ribonucleic acid polymerase. Since ribavirin is phosphorylated in the cell, the inhibition of influenza multiplication in the cell may also be caused by RTP.

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References

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