Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1996 Mar;75(3):287-90.
doi: 10.1136/hrt.75.3.287.

Abnormal cytokine profiles in patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives

J B Marriott  1 , J H Goldman, P J Keeling, M K Baig, A G Dalgleish, W J McKenna
Affiliations
Comparative Study

Abnormal cytokine profiles in patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives

J B Marriott et al. Heart. 1996 Mar.

Abstract

Objectives: Immunological abnormalities in idiopathic dilated cardiomyopathy (DCM) include an increase in soluble interleukin (IL)-2 receptor, disease specific cardiac autoantibodies, an HLA-DR4 association, and familial aggregation of disease; however, cytokine profiles have not been defined. Serum concentrations of IL-2, IL-4, IL-10, and IL-12 were measured in patients with DCM (WHO criteria), relatives with asymptomatic left ventricular enlargement (LVE), patients with ischaemic heart failure (IHD), and healthy controls.

Design: Serum from 20 individuals from each of the four groups was assayed for cytokine concentrations by a commercial enzyme linked immunosorbent assay.

Results: IL-2 concentrations were abnormally increased in DCM patients and relatives with LVE. Concentrations of IL-10 were increased in DCM patients. Concentrations of IL-4 and IL-12 were not increased in any of the groups.

Conclusion: These abnormalities may reflect defective/inappropriate T cell function in patients with DCM and in their relatives with LVE.

PubMed Disclaimer

References

    1. Circulation. 1980 Nov;62(5):1054-61 - PubMed
    1. Br Heart J. 1994 Dec;72(6):561-6 - PubMed
    1. Am J Cardiol. 1984 May 1;53(9):1326-30 - PubMed
    1. Am J Cardiovasc Pathol. 1987 Jan;1(1):3-14 - PubMed
    1. Annu Rev Immunol. 1989;7:145-73 - PubMed

Publication types