doi: 10.1007/BF00520191.
Expression of alpha-D-mannosidase in man-hamster somatic cell hybrids
- PMID: 880209
- DOI: 10.1007/BF00520191
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Expression of alpha-D-mannosidase in man-hamster somatic cell hybrids
Biochem Genet.
1977 Jun.
Abstract
Two types of alpha-D-mannosidase isozymes are present in human white blood cells, human diploid fibroblasts, and HeLa cells. One of these (the S isozyme) constitutes the major alpha-D-mannosidase of the human cells, has a pH optimum of 4.4, and is associated with lysosomes. The other (the F isozyme) is most active at pH 6, is acid labile, and is located in the soluble portion of the cytoplasm. The expression of human lysosomal alpha-D-mannosidase was examined in man-hamster hybrid clones, and was found to be concordant with that of phosphohexose isomerase in 54 of 55 primary clones. A locus specifying human lysosomal alpha-D-mannosidase has therfore been assigned to chromosome 19.
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