doi: 10.1042/bj1640281.
Cellular transport of lysosomal enzymes: an alternative hypothesis
- PMID: 880235
- PMCID: PMC1164786
- DOI: 10.1042/bj1640281
Item in Clipboard
Cellular transport of lysosomal enzymes: an alternative hypothesis
Biochem J.
.
Abstract
Hickman & Neufeld [(1972) Biochem, Biophys. Res. Commun. 49, 992-999] have proposed that lysosomal enzymes reach the lysosomes by means of exocytosis and subsequent pinocytic reincorporation. The results leading to this conclusion are re-assessed and an alternative explanation is advanced that relates to the necessity for membrane recycling in endocytic cells.
Similar articles
-
An alternative hypothesis of cellular transport of lysosomal enzymes in fibroblasts. Effect of inhibitors of lysosomal enzyme endocytosis on intra- and extra-cellular lysosomal enzyme activities.Biochem J. 1978 Dec 15;176(3):943-50. doi: 10.1042/bj1760943. Biochem J. 1978. PMID: 747663 Free PMC article.
-
Insights into mechanisms of intracellular protein turnover from studies on pinocytosis.Ciba Found Symp. 1979;(75):151-65. doi: 10.1002/9780470720585.ch10. Ciba Found Symp. 1979. PMID: 399888 Review.
-
A quantitative study of pinocytosis and lysosome function in experimentally induced lysosomal storage.Biochem J. 1976 Dec 15;160(3):621-9. doi: 10.1042/bj1600621. Biochem J. 1976. PMID: 1016242 Free PMC article.
-
The phosphomannosyl recognition system for intracellular and intercellular transport of lysosomal enzymes.J Cell Biochem. 1982;18(1):67-85. doi: 10.1002/jcb.1982.240180107. J Cell Biochem. 1982. PMID: 6279685 Review. No abstract available.
-
Lysosomal enzymes may cross the blood-brain-barrier by pinocytosis: implications for enzyme replacement therapy.Med Hypotheses. 2014 Apr;82(4):478-80. doi: 10.1016/j.mehy.2014.01.029. Epub 2014 Feb 5. Med Hypotheses. 2014. PMID: 24560457
Cited by
-
Excretion-reuptake route of beta-hexosaminidase in normal and I-cell disease cultured fibroblasts.J Clin Invest. 1979 Apr;63(4):595-601. doi: 10.1172/JCI109341. J Clin Invest. 1979. PMID: 438323 Free PMC article.
-
Comparison of the alpha-mannosidases in fibroblast cultures from patients with mannosidosis and mucolipidosis II and from controls.Biochem J. 1980 May 1;187(2):541-3. doi: 10.1042/bj1870541. Biochem J. 1980. PMID: 7396862 Free PMC article.
-
An alternative hypothesis of cellular transport of lysosomal enzymes in fibroblasts. Effect of inhibitors of lysosomal enzyme endocytosis on intra- and extra-cellular lysosomal enzyme activities.Biochem J. 1978 Dec 15;176(3):943-50. doi: 10.1042/bj1760943. Biochem J. 1978. PMID: 747663 Free PMC article.
-
New form of acid phosphatase during lysosome biogenesis.Biochem J. 1981 Jul 15;198(1):9-15. doi: 10.1042/bj1980009. Biochem J. 1981. PMID: 7326004 Free PMC article.
-
Effect of tunicamycin and cycloheximide on the secretion of acid hydrolases from I-cell cultured fibroblasts.Biochem J. 1980 Mar 15;186(3):971-5. doi: 10.1042/bj1860971. Biochem J. 1980. PMID: 7396846 Free PMC article.
References
MeSH terms
LinkOut - more resources
Full Text Sources
