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Review
. 1996 Jun;6(3):327-33.
doi: 10.1016/s0959-440x(96)80051-0.

Oligonucleotide directed triple helix formation

J S Sun  1 , T Garestier, C Hélène
Affiliations
Review

Oligonucleotide directed triple helix formation

J S Sun et al. Curr Opin Struct Biol. 1996 Jun.

Abstract

Oligonucleotide directed triple helix formation allows the sequence-specific recognition of the major groove of double-helical DNA. Recently synthesized base analogs and backbones, such as N3'-->P5' phosphoramidates, allow stable triplexes to be formed under physiological conditions. However, it remains a challenge to design new oligomers that would extend the range of recognition sequences (which are still limited to oligopurine-rich tracts). Oligonucleotide directed triple helix formation could be used to control biological processes such as transcription and replication. Three-stranded structures formed during recombination processes have been further characterized.

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