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. 1996 Jul;40(7):1600-3.
doi: 10.1128/AAC.40.7.1600.

Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors

P J Rosenthal  1 , J E Olson, G K Lee, J T Palmer, J L Klaus, D Rasnick
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Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors

P J Rosenthal et al. Antimicrob Agents Chemother. 1996 Jul.

Abstract

We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine proteinase that is a critical hemoglobinase. In studies of cultured parasites, nanomolar concentrations of three vinyl sulfones inhibited parasite hemoglobin degradation, metabolic activity, and development. The antimalarial effects correlated with the inhibition of falcipain. Our results suggest that vinyl sulfones or related cysteine proteinase inhibitors may have promise as antimalarial agents.

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References

    1. J Parasitol. 1979 Jun;65(3):418-20 - PubMed
    1. J Med Chem. 1995 Dec 22;38(26):5031-7 - PubMed
    1. J Clin Invest. 1988 Nov;82(5):1560-6 - PubMed
    1. Mol Biochem Parasitol. 1989 Jun 15;35(2):177-83 - PubMed
    1. Ann N Y Acad Sci. 1989;569:1-16 - PubMed

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