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Clinical Trial
. 1996 Jul;40(7):1720-1.
doi: 10.1128/AAC.40.7.1720.

Dose-ranging study of CP-99,219 (trovafloxacin) for treatment of uncomplicated gonorrhea

E W Hook 3rd  1 , G B Pinson, C J Blalock, R B Johnson
Affiliations
Clinical Trial

Dose-ranging study of CP-99,219 (trovafloxacin) for treatment of uncomplicated gonorrhea

E W Hook 3rd et al. Antimicrob Agents Chemother. 1996 Jul.

Abstract

Thirty-nine patients with uncomplicated gonorrhea were randomized to receive single, oral 50-, 100-, or 200-mg doses of trovafloxacin (CP-99,219), a new quinolone antibiotic. All 31 evaluable patients were cured of infection. Trovafloxacin was well tolerated. The trovafloxacin MICs at which 50 and 90% of 36 Neisseria gonorrhoeae isolates are inhibited were 0.002 and 0.004 mg/liter, respectively (MIC range, < 0.0005 to 0.008 mg/liter). These preliminary studies suggest that trovafloxacin is effective for the treatment of uncomplicated gonorrhea at single oral doses as low as 50 mg.

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