Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Jul;40(7):1726-8.
doi: 10.1128/AAC.40.7.1726.

Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas

J Tamaoki  1 , J Nakata, E Tagaya, K Konno
Affiliations

Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas

J Tamaoki et al. Antimicrob Agents Chemother. 1996 Jul.

Abstract

Inhaled interleukin 8 caused an increase in goblet cell secretion in guinea pig tracheas, which was accompanied by mucosal infiltration of neutrophils. These responses were inhibited by pretreatment with roxithromycin or erythromycin in a dose-dependent fashion. Macrolides may thus be a value in protecting against neutrophil-associated airway hypersecretion.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Am Rev Respir Dis. 1975 Jul;112(1):65-9 - PubMed
    1. J Antimicrob Chemother. 1986 Feb;17(2):195-203 - PubMed
    1. Am Rev Respir Dis. 1987 Nov;136(5):1207-12 - PubMed
    1. J Clin Invest. 1989 Oct;84(4):1045-9 - PubMed
    1. Antimicrob Agents Chemother. 1995 Aug;39(8):1688-90 - PubMed

Publication types