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. 1996 Jul;40(7):1733-5.
doi: 10.1128/AAC.40.7.1733.

Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock

F Genovese  1 , G Mancuso, M Cuzzola, V Cusumano, F Nicoletti, K Bendtzen, G Teti
Affiliations

Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock

F Genovese et al. Antimicrob Agents Chemother. 1996 Jul.

Abstract

Unlike the antibiotics erythromycin and penicillin G, sodium fusidate (fusidin) pretreatment (80 mg/kg of body weight) increased the survival rate of neonatal BALB/c mice challenged with Salmonella enteritidis lipopolysaccharide. Fusidin also significantly reduced the plasma tumor necrosis factor alpha levels. Hence, fusidin may prove useful in the management of bacterial sepsis in humans.

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