Abstract

PIP: A d-norgestrel-releasing IUD was introduced into the uterine cavity of 18 healthy women. The carrier material for d-norgestrel was silastic attached to the vertical arm of a Nova-T. 2 kinds of d-norgestrel IUDs were used, with d-norgestrel-releasing surface areas of 83 sq mm and 132 sq mm, respectively. The determination of plasma concentrations of estradiol and progesterone showed that ovulation occurred in 8 of 12 subjects thus assayed. Endometrial biopsies showed uniform suppression. The bleeding pattern was carefully registered and found to be fairly regular and significantly reduced in amount. d-Norgestrel concentrations ranged between .1-.2 ng/ml. During a total of 60 woman-months the pregnancy rate was zero.