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. 1977 Jan-Mar;4(1):49-55.

Circadian study on serum gastrin in patients with duodenal ulcers and in a control group

B Tarquini, A Brocchi, L Buricchi, G Cappelli, A Costa, B Neri, M Cagnoni
  • PMID: 880852

Circadian study on serum gastrin in patients with duodenal ulcers and in a control group

B Tarquini et al. Chronobiologia. 1977 Jan-Mar.

Abstract

Two groups of subjects (one consisting of fourteen apparently healthy subjects, the other of fourteen patients with peptic ulcers) were kept for a least 7 days on the same living schedule (nocturnal sleep for 22(00) to 05(00) and meals standardized at 08(00)-08(30), 12(00)-12(30), 17(30)-18(00)). During 24 hors, samples of venous blood were obtained from each subject every 4 hours for the serum gastrin radioimmunoassay. The results were analyzed by mean cosinor method. The control group has a statistically significant circadian rhythm, while we were not able to detect a circadian rhythm in the patients with duodenal ulcers. The daily mean of serum gastrin levels appears to be significantly reduced in the ulcer group.

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