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. 1996 Sep;51(5):M220-2.
doi: 10.1093/gerona/51a.5.m220.

The relationship of aging to endotoxin shock and to production of TNF-alpha

H N Chang  1 , S R Wang, S C Chiang, W J Teng, M L Chen, J J Tsai, D F Huang, H Y Lin, Y Y Tsai
Affiliations

The relationship of aging to endotoxin shock and to production of TNF-alpha

H N Chang et al. J Gerontol A Biol Sci Med Sci. 1996 Sep.

Abstract

Background: Aged people are considered prone to gram-negative bacteremia and septic shock. This relationship was tested in murine endotoxin shock.

Methods: Balb/c mice of various ages (1.4-13.4 months) were intraperitoneally injected with lipopolysaccharide (LPS), and rates of survival were observed. The production of TNF-alpha in vivo induced by LPS was measured.

Results: The survival rates were the smallest in the oldest and youngest groups. Production of TNF-alpha attained a maximum at 2 h after LPS injection and was smaller in the oldest group; it had a reciprocal relationship to survival rates in each group except the youngest group.

Conclusion: Old and young mice had smaller rates of survival and greater production of TNF-alpha following endotoxin shock induced by LPS.

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