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. 1977;22(4):242-8.

Dog liver 3-hydroxy-3-methylglutaryl coenzyme A reductase

P P Ho, M A Esterman, R D Towner, R K Turner
  • PMID: 880941

Dog liver 3-hydroxy-3-methylglutaryl coenzyme A reductase

P P Ho et al. Enzyme. 1977.

Abstract

A rapid and sensitive assay method for 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-coA reductase, EC 1.1.1.34) is described. HMG-coA reductase is demonstrated in dog liver microsomes, and the converted reaction product has been identified as mevalonolactone. The enzyme activity undergoes cyclic variation and increases by more than tenfold 5 h after feeding. The properties of dog liver enzyme are generally similar to the rat liver enzyme in the method of solubilization, cold inactivation, pH optimum, and Km values.

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