Clinical Trial
Cardiotoxic properties of cocaine: studies with positron emission tomography
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- PMID: 8809858
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Clinical Trial
Cardiotoxic properties of cocaine: studies with positron emission tomography
NIDA Res Monogr.
1996.
Abstract
This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.
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